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TMAO, which can also be formed from choline as a precursor, is itself associated with an increased risk of CVD despite being naturally found in some species of fish and seafood

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To test this, lineage-negative cells isolated from Mx1-T3 and Mx1-Cre mice treated with or without -glucan were differentiated into myeloid cells ex vivo, treated with or without -glucan, and subsequently stimulated with LPS (Extended Data Fig

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24 The peptides ability to modulate nitric oxide and inflammatory cytokines may underlie these effects

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